Laboratory of Immunochemistry
Print versionHead of the laboratory – Doctor of Biological Sciences (DSc. in Biology), Professor
Viktor V. Novikov
The laboratory of biochemistry was organized in 1969.Research was aimed at studying the structure and function of serum proteins in order to develop therapeutic and prophylactic blood products, as well as at studying the immunological properties of various classes of immunoglobulins.
Directions of activities:
- Proteomic blood test, the study of the biological role of natural autoantibodies and autoimmune processes.
- Evaluation of the effectiveness and safety of the use of immunobiological preparations, prophylactic vaccines.
- Development of diagnostic and therapeutic drugs based on targeted molecules.
Laboratory achievements:
- An industrial method has been developed for obtaining the first immunoglobulin preparation in the USSR for intravenous administration. Developers headed by Academician of the Academy of Medical Sciences of the USSR I.N. Blokhinawere awarded the USSR State Prize.
- Technologies have been developed to obtain preparations of enriched immunoglobulin for oral administration, monomeric immunoglobin for intravenous administration.
- Experimental and laboratory technology for the preparation of therapeutic drug ceruloplasmin has been developed.
- The methods of production and purification of serum proteins (alpha 2-macroglobulin, transferrin, immunoglobulins, etc.), development of diagnostic preparations for determination and evaluation of functional activity of serum proteins and human tissues - metalloproteins (ferritin, myoglobin, lactoferrin), fibrogen and fibrin/fibrinogen degradation products, a wide range of autoantibodies were optimized.
- A comprehensive method for assessing the strength of local and systemic immunity to diphtheria has been developed, which allows differential analysis of antibodies to bacterial antibodies and exoproducts of corynebacteria.
- A complex of universal reagents for determining class-specific human antibodies specific to IgM(mu-chain, Fc- fragment), IgA (secretory component, alpha1,2-chain, polymeric determinant) in an enzyme immunoassay has been developed.
- Screening methods of integrated assessment of autoimmune and destructive-restorative process at hepatitis of different etiology have been developed.
- A comprehensive (at the level of humoral and cellular immunity) method for assessing the safety and efficacy of prophylactic vaccines and immunobiological preparations has been elaborated.
Prospects:
- In 2019 the researches on development of recombinant vaccine of new generation for prevention of an enteroviral infection are initiated.
Phone: +7(831) 469-79-56 Victor V. Novikov
469-79-55 general issues
E-mail: lab.imchem@nniiem.ru
Address: 603950, Nizhny Novgorod, Malaya Yamskaya st., 71, 7th floor.
